Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 166, Issue -, Pages 231-238Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2012.02.046
Keywords
Nanostructured film; Biosensor; Information visualization; Multidimensional projection; Lipase; Glucose oxidase
Funding
- FAPESP
- CNPq
- Capes
- rede nBioNet
- LNLS (Brazil) [LMF 11325]
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In this paper we discuss the detection of glucose and triglycerides using information visualization methods to process impedance spectroscopy data. The sensing units contained either lipase or glucose oxidase immobilized in layer-by-layer (LbL) films deposited onto interdigitated electrodes. The optimization consisted in identifying which part of the electrical response and combination of sensing units yielded the best distinguishing ability. It is shown that complete separation can be obtained for a range of concentrations of glucose and triglyceride when the interactive document map (IDMAP) technique is used to project the data into a two-dimensional plot. Most importantly, the optimization procedure can be extended to other types of biosensors, thus increasing the versatility of analysis provided by tailored molecular architectures exploited with various detection principles. (C) 2012 Elsevier B.V. All rights reserved.
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