Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 156, Issue 2, Pages 825-831Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.02.048
Keywords
Fluorescence; Zinc; Water-solubility; Cell imaging; Biocompatibility
Funding
- Science Foundation of Jiangsu Province [BK2006717]
- National Natural Science Foundation of China [40930742]
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By combining a sulfonated beta-naphtol as receptor, a hydrophilic fluorescence probe with extreme sensitivity (7 ppb) and selectivity for zinc ion has been designed and synthesized in a simple and efficient way. Based on the inhibition of internal charge transfer (ICT) process, This turn-on type fluorescent sensor molecule features high fluorescence increase (13 fold) at 508 nm as well as a red-shift from 371 to 430 nm over most competitive heavy and transition metal (HTM) ions in water (pH 7.4). Furthermore, cell imaging experiments show that this fluorescence probe might be used for monitoring Zn(2+) within biological samples. The role of this sensor molecule in living cells was further confirmed with the treatment of N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine. And the impact of water-solubility and liposolubility of such fluorescence probe on biological application has been deeply discussed. (C) 2011 Elsevier B.V. All rights reserved.
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