Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 160, Issue 1, Pages 747-752Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.08.058
Keywords
NC membrane; Magnetic beads; Hybrid AMR/PHR ring sensors; Cardiac Troponin I; Antibody; Antigen
Funding
- WCU (World Class University) through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [R32-20026]
- National Research Foundation of Korea [R32-2011-000-20026-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cardiac Troponin I (cTnI) functionalized immunomagnetic beads in lateral flow membrane was measured to analyze the analyte kinetics of mass-transport and antibody-antigen binding reaction. A hybrid AMR/PHR (Anisotropic magnetoresistance/Planar Hall resistance) ring sensor exhibits self-balanced bridge characteristics for each branch with an additive magnetic field effect and its field sensitivity was 135 mu V/Oe for the +/- 50 Oe range. The real time monitoring of the sensor voltage for the cTnI concentrations in the range of 0.44-2.2 nM exhibits a two-step increment with time. A rapid increment in early time regime up to 50s is related with the kinetics of antibody-antigen binding reactions, and then a gradual increment is governed by the kinetics of analyte transportation. The sensor voltage variation in early time regime was equal to 70% of the total variation at 400 s. (C) 2011 Elsevier B.V. All rights reserved.
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