Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 149, Issue 2, Pages 373-380Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2010.06.049
Keywords
Gold nanoparticle biosensors; Ligand-exchange; 2D nucleation; Resonance elastic light scattering (RELS); Surface plasmon
Funding
- U.S. DoD [AS073218]
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A new method for rapid functionalization of metal nanoparticles based on a moderator-tunable 2D nucleation and growth of ligand-exchange domains has been developed for the design of biosensors with nanoparticle-enhanced sensory films and other applications. The proposed functionalization of gold nanoparticles proceeds through the nucleation and avalanche growth of ligand-exchange domains in the self-assembled monolayer film on a gold nanoparticle surface. The nucleation and growth is controllable by a moderator molecule. The experimental system described presents a ligand-exchange process at citrate-capped gold nanoparticles, with homocysteine acting as the incoming ligand and glutathione as the moderator. The kinetics of the nucleation and growth driven ligand-exchange is characterized by a sigmoidal switching function and differs from that of the usually observed Langmuirian pseudo-first-order process corresponding to the random place-exchange. The ultra-fast functionalization process was monitored using resonance elastic light scattering (RELS) spectroscopy and confirmed by UV-vis plasmonic band absorbance measurements. (C) 2010 Elsevier B.V. All rights reserved.
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