Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 144, Issue 2, Pages 413-417Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2009.02.003
Keywords
Optical grating coupler; Multi-channel biorecognition; On-chip reference
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In this paper, a multiple-channel extension of a dual-grating Coupler biosensor is presented as a Solution for the problem of resolving different selectivities, Usual when heterogeneous samples are analyzed. Several differently functionalized channels can perform quantitative analysis of competiting recognition events, Suppress shifts due to buffer changes and even monitorize drifts coming from the light Source. Here, the multiple-channel approach is developed and proven for a four-channel configuration, providing a resolution limit of 10(-5) Refractive index Units (RIU) and with an a potentially Unlimited scalability. Finally, a differential HSA recognition event is monitored, at both an IgG functionalized channel and at a blocked one. (C) 2009 Elsevier B.V. All lights reserved.
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