Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 148, Issue 2, Pages 492-497Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2010.05.005
Keywords
Carbon nanotubes; Cobalt phthalocyanine; Epinephrine; Composite electrode; Human urine samples
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2007/59201-4]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
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This paper describes the development, electrochemical characterization and utilization of a cobalt phthalocyanine (CoPc), modified multi-walled carbon nanotube (MWCNT), and paraffin composite electrode for the quantitative determination of epinephrine (EP) in human urine samples. The electrochemical profile of the proposed composite electrode was analyzed by differential pulse voltammetry (DPV) that showed a shift of the oxidation peak potential of EP at 175 mV to less positive value, compared with a paraffin/graphite composite electrode without CoPc. DPV experiments in PBS at pH 6.0 were performed to determine EP without any previous step of extraction, clean-up, and derivatization, in the range from 1.33 to 5.50 mu mol L-1, with a detection limit of 15.6 nmol L-1 (2.86) of EP in electrolyte prepared with purified water. The lifetime of the proposed sensors was at least over 1000 determinations with 1.7 and 3.1 repeatability and reproducibility relative standard deviations, respectively. Human urine samples without any purification step were successfully analyzed under the standard addition method using paraffin/MWCNT/CoPc composite electrode. (C) 2010 Elsevier B.V. All rights reserved.
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