Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 142, Issue 2, Pages 451-456Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2009.04.062
Keywords
Poly(ethylenedioxythiophene) (PEDOT); Electrospinning; Poly(ethylene terephthalate) (PET); Cell stimulation; SH-SY5Y neuroblastoma cells; Nano-fibers
Funding
- Swedish Foundation for Strategic Research (SSF)
- Linkoping University
- Royal Swedish Academy of Sciences
- Swedish Research Council
- IRECO Holding
- Knut and Alice Wallenberg Foundation
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Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling. (C) 2009 Elsevier B.V. All rights reserved.
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