Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 142, Issue 1, Pages 191-196Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2009.08.002
Keywords
Fluorescence; Chemosensor; Imaging; Mercury ion; Living cells; Anions
Funding
- NSF of China [20706008, 20725621, 20872012]
- National Basic Research Program of China [2009CB724706]
- Ministry of Education of China [20070141052]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0711]
- Cultivation Fund of the Key Scientific and Technical Innovation Project [707016]
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A fluorescent chemosensor, B2, for Hg2+ containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg2+ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg2+ in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg2+ in living cells. (C) 2009 Elsevier B. V. All rights reserved.
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