A sensitive and selective sensor for dopamine determination based on a molecularly imprinted electropolymer of o-aminophenol

A simple and reliable method was proposed for preparing a selective dopamine (DA) sensor based on a molecularly imprinted electropolymer of o-aminophenol. The sensor is selective for the determination of DA in the presence of high concentrations of ascorbic acid (AA), with a maximum molar ratio of 1/1000. The molecular imprinted (MIP) sensor was tested by cyclic voltammetry (CV) as well as differential pulse voltammetry (DPV) to verify the changes in oxidative currents of ferricyanide. In optimized conditions, DA at concentrations of 2 x 10(-8) to 0.25 x 10(-6) mol/L could be determined with a detection limit of 1.98 x 10(-9) mol/L(S/N = 3). The MIP sensor showed high selectivity, sensitivity, and reproducibility. Determination of DA in simulated samples of dopamine hydrochloride showed good recovery. (C) 2009 Elsevier B.V. All rights reserved.