Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 134, Issue 1, Pages 292-299Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2008.05.002
Keywords
Modified glassy carbon electrode; Multiwall carbon nanotube; Noscapine; Cyclic voltammetry
Funding
- Isfahan University of Technology (IUT)
- Research Council and Center of Excellence in sensor (IUT)
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A simple and highly sensitive method is described for direct voltammetric determination of noscapine in blood and pharmaceutical sample. Glassy carbon electrode with effective method is modified with multiwall carbon nanotubes (MWNTs) to cause activation of multiwall carbon nanotubes structures for electrocatalyzes of noscapine oxidation. The cyclic voltammetric (CV) results indicated that MWNTs remarkably enhances electrocatalytic activity toward the oxidation of noscapine, which is leading to considerable improvement of anodic peak current for noscapine, and allows the development of a highly sensitive voltammetric sensor for detection of noscapine in pharmaceutical and clinical samples. Under the optimum condition, the calibration curve was linear in the concentration range 4.0 x 10(-7) -1.0 x 10(-4) mol L-1 with the detection limit of 8.0 x 10(-8) mol L-1 and relative standard deviation (R.S.D.%) lower than 1.0% (n = 5). Finally, some kinetic parameters were determined and multistep mechanism for oxidation of noscapine for first time was proposed. (C) 2008 Elsevier B.V. All rights reserved.
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