Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 133, Issue 2, Pages 628-631Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2008.03.044
Keywords
surface plasmon resonance; biosensor; p-polarization
Funding
- Natural Science and Engineering Research Council of Canada
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We here describe a scheme of spatially modulated surface plasmon resonance (SPR) polarimetry that enables to combine ultra-high phase sensitivity with good signal-to-noise background. The proposed approach uses spatial modulation of s-polarized component by birefringent elements and the extraction of phase-polarization in formation by Fourier-transform methods. This scheme was tested for monitoring the interactions between an antibody and its biological partner. Our experimental data, collected by amplitude-sensitive and phase-sensitive polarimetry demonstrate that the latter scheme provides at least one order of magnitude improvement in terms of detection limit. (C) 2008 Elsevier B.V. All rights reserved.
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