4.7 Article

Effect of microneedles shape on skin penetration and minimally invasive continuous glucose monitoring in vivo

Journal

SENSORS AND ACTUATORS A-PHYSICAL
Volume 203, Issue -, Pages 373-381

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.sna.2013.09.026

Keywords

Microneedle array; Microneedle shape; Interstitial fluid; Skin penetration; Crack propagation; Continuous glucose monitoring

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The effect of microneedle shape on skin penetration and minimally invasive continuous glucose monitoring (CGM) was successfully investigated. Straight silicon microneedle arrays (SSMA) and tapered silicon microneedle arrays (TSMA) were fabricated using standard silicon micromachining techniques. Microneedle heights were similar to 325 mu m and similar to 350 mu m and pitch was 400 mu m and 450 mu m, respectively. Mode-I planar crack and mode-II ring crack propagation were assumed for TSMA and SSMA penetration mechanisms, respectively. Skin penetration was first qualitatively evaluated via methylene blue staining. TSMA and SSMA were also mounted on CGM system prototypes and applied on human subjects with an impact velocity of 10 m/s and worn for 6.5 h. The hollow microneedles allowed the glucose from the interstitial fluid in the epidermis to diffuse into the sensor chamber of the CGM system prototype. Sensor currents from the applied CGM system prototypes ranged from 100 nA to 400 nA and they appeared to follow the trend of the reference blood glucose sensor that ranged from similar to 90 to 220 mg/dL. The CGM system prototype with SSMA yielded lower sensor current than that with TSMA. This may be due to the SSMA preferential penetration of skin via mode-II ring crack propagation, resulting in possible lumen occlusion from displaced skin material. (C) 2013 Elsevier B.V. All rights reserved.

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