Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14170
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Funding
- Hong Kong Research Grant Council [RGC-GRF 17127714]
- Health and Medical Research Fund of the Hong Kong Government [RRG-10, RRG-14]
- Shenzhen Peacock Plan High-End Talents Program [KQTD201203]
- National Nature Science Foundation of China [81341003]
- Li Ka Shing Foundation
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The ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that dual 627K and 701N mutations could readily occur during transmission of the virus among ferrets via direct physical contact, and these mutations conferred higher polymerase activity and improved viral replication in mammalian cells, and enhanced virulence in mice. Special attention needs to be paid to patients with such mutations, as these may serve as an indicator of higher virus replication and increased pathogenicity.
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