Journal
SENSORS
Volume 18, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/s18092755
Keywords
stem cells; differentiation; pluripotency; electrochemical detection; Raman spectroscopy
Funding
- Chung-Ang University Graduate Research Scholarship in 2016
- Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) - Korea Government (MSIP) [NRF-2014M3A7B4051907]
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Breakthroughs in the biomedical and regenerative therapy fields have led to the influential ability of stem cells to differentiate into specific types of cells that enable the replacement of injured tissues/organs in the human body. Non-destructive identification of stem cell differentiation is highly necessary to avoid losses of differentiated cells, because most of the techniques generally used as confirmation tools for the successful differentiation of stem cells can result in valuable cells becoming irrecoverable. Regarding this issue, recent studies reported that both Raman spectroscopy and electrochemical sensing possess excellent characteristics for monitoring the behavior of stem cells, including differentiation. In this review, we focus on numerous studies that have investigated the detection of stem cell pluripotency and differentiation in non-invasive and non-destructive manner, mainly by using the Raman and electrochemical methods. Through this review, we present information that could provide scientific or technical motivation to employ or further develop these two techniques for stem cell research and its application.
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