Journal
SENSORS
Volume 14, Issue 3, Pages 4948-4959Publisher
MDPI AG
DOI: 10.3390/s140304948
Keywords
surface plasmon resonance (SPR); SPR imaging (SPRI); biosensor; clinical diagnosis; diagnosis of allergy; diagnosis of cancer; optic fiber SPR
Funding
- Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER) from Hiroshima Prefectural Institute of Industrial Science and Technology, Japan
- Innovation Plaza Hiroshima of JST (Japan Science and Technology Corporation)
- Takeda Science Foundation
- Program for Promotion of Basic and Applied Researches for Innovation in Bio-oriented Industry
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Non-invasive real-time observations and the evaluation of living cell conditions and functions are increasingly demanded in life sciences. Surface plasmon resonance (SPR) sensors detect the refractive index (RI) changes on the surface of sensor chips in label-free and on a real-time basis. Using SPR sensors, we and other groups have developed techniques to evaluate living cells' reactions in response to stimuli without any labeling in a real-time manner. The SPR imaging (SPRI) system for living cells may visualize single cell reactions and has the potential to expand application of SPR cell sensing for clinical diagnosis, such as multi-array cell diagnostic systems and detection of malignant cells among normal cells in combination with rapid cell isolation techniques.
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