Journal
SENSORS
Volume 13, Issue 10, Pages 12794-12803Publisher
MDPI AG
DOI: 10.3390/s131012794
Keywords
ischemia modified albumin; surface plasmon resonance immunosensor; gold nanoparticles; signal enhancement
Funding
- National Science Foundation of China [30500125]
- National Science Foundation of Chongqing [2008BB5395]
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In this study a novel sensitive nanogold particle sensor enhancement based on mixed self-assembled monolayers was explored and used to construct a Surface Plasmon Resonance (SPR) immunosensor to detect Ischemia Modified Albumin (IMA). Compared with a direct binding SPR assay at a limit of detection (LOD) of 100 ng/L, gold nanoparticles (AuNPs) of 10 nm dramatically improved the LOD of IMA to 10 ng/L. Meanwhile, no interfering substance that may lead to false positive results was identified. These results suggested that the SPR biosensor presented superior properties, and provided a simple label-free strategy to increase assay sensitivity for further acute coronary syndrome (ACS) diagnosis.
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