Journal
SENSORS
Volume 13, Issue 4, Pages 4214-4224Publisher
MDPI
DOI: 10.3390/s130404214
Keywords
amplified competitive lateral flow assay; lead ions; immunosensor; gold nanoparticles
Funding
- National Natural Science Foundation of China [21071066, 91027038, 21101079, 21175034]
- Key Programs from MOST [2012BAC01B07, 2012BAD29B05, 2012AA06A303, 2012BAD29B04, 2011BAK10B07, 2011BAK10B05, 2011BAK10B01, 2010AA06Z302, 2010DFB3047, 2011ZX08012-001, 2012BAK17B10, 2012BAK08B01, 2012YQ090194]
- Jiangsu Province
- MOF
- MOE [NCET-12-0879, BE2011626, 201210036, 201310135, 311002]
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In this study, we have first developed a rapid and sensitive strip immunosensor based on two heterogeneously-sized gold nanoparticles (Au NPs) probes for the detection of trace lead ions in drinking water. The sensitivity was 4-fold higher than that of the conventional LFA under the optimized conditions. The visual limit of detection (LOD) of the amplified method for qualitative detection lead ions was 2 ng/mL and the LOD for semi-quantitative detection could go down to 0.19 ng/mL using a scanning reader. The method suffered from no interference from other metal ions and could be used to detect trace lead ions in drinking water without sample enrichment. The recovery of the test samples ranged from 96% to 103%. As the detection method could be accomplished within 15 min, this method could be used as a potential tool for preliminary monitoring of lead contamination in drinking water.
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