Journal
SENSORS
Volume 12, Issue 7, Pages 9530-9550Publisher
MDPI
DOI: 10.3390/s120709530
Keywords
biomimetic membranes; lipid bilayer; ion channel sensors
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2009-0088893, 2012R1A1B4002413]
- Inha University Research Grant
- National Research Foundation of Korea [2012R1A1B4002413, 2009-0088893] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Synthetic biomimetic membranes provide biological environments to membrane proteins. By exploiting the central roles of biological membranes, it is possible to devise biosensors, drug delivery systems, and nanocontainers using a biomimetic membrane system integrated with functional proteins. Biomimetic membranes can be created with synthetic lipids or block copolymers. These amphiphilic lipids and polymers self-assemble in an aqueous solution either into planar membranes or into vesicles. Using various techniques developed to date, both planar membranes and vesicles can provide versatile and robust platforms for a number of applications. In particular, biomimetic membranes with modified lipids or functional proteins are promising platforms for biosensors. We review recent technologies used to create synthetic biomimetic membranes and their engineered sensors applications.
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