Journal
SENSORS
Volume 12, Issue 4, Pages 5005-5027Publisher
MDPI
DOI: 10.3390/s120405005
Keywords
glucose homeostasis; fluorescent-tagged glucose; bioprobe; bioimaging
Funding
- National Research Foundation
- Korean government (MEST) [NRF-2010-0006002]
- MEST [NRF-2009-0067894]
- Bioimaging Research Center at GIST
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Glucose homeostasis is a fundamental aspect of life and its dysregulation is associated with important diseases, such as cancer and diabetes. Traditionally, glucose radioisotopes have been used to monitor glucose utilization in biological systems. Fluorescent-tagged glucose analogues were initially developed in the 1980s, but it is only in the past decade that their use as a glucose sensor has increased significantly. These analogues were developed for monitoring glucose uptake in blood cells, but their recent applications include tracking glucose uptake by tumor cells and imaging brain cell metabolism. This review outlines the development of fluorescent-tagged glucose analogues, describes their recent structural modifications and discusses their increasingly diverse biological applications.
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