Journal
SENSORS
Volume 12, Issue 11, Pages 15078-15087Publisher
MDPI AG
DOI: 10.3390/s121115078
Keywords
gold nanoparticles; adenosine triphosphate; colorimetric assay; metal ions
Funding
- National Natural Science Foundation of China [21105002, 21205003, 21201010]
- Science & Technology Foundation of Henan Province [122102310517]
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We report a simple, fast and selective colorimetric assay of adenosine triphosphate (ATP) using unmodified gold nanoparticles (AuNPs) as probes and metal ions as cross-linkers. ATP can be assembled onto the surface of AuNPs through interaction between the electron-rich nitrogen atoms and the electron-deficient surface of AuNPs. Accordingly, Cu2+ ions induce a change in the color and UV/Vis absorbance of AuNPs by coordinating to the triphosphate groups and a ring nitrogen of ATP. A detection limit of 50 nM was achieved, which is comparable to or lower than that achievable by the currently used electrochemical, spectroscopic or chromatographic methods. The theoretical simplicity and high selectivity reported herein demonstrated that AuNPs-based colorimetric assay could be applied in a wide variety of fields by rationally designing the surface chemistry of AuNPs. In addition, our results indicate that ATP-modified AuNPs are less stable in Cu2+, Cd2(+) or Zn2+-containing solutions due to the formation of the corresponding dimeric metal-ATP complexes.
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