4.6 Article

Label-Free Microcavity Biosensors: Steps towards Personalized Medicine

Journal

SENSORS
Volume 12, Issue 12, Pages 17262-17294

Publisher

MDPI
DOI: 10.3390/s121217262

Keywords

biosensors; microsensors; microcavity surface plasmon resonance; proteomics; interactomics; microfluidics; personalized medicine; biomarkers; single cell secretion

Funding

  1. NSF/IBDR [DBI-1152030]
  2. Office of the Vice President for Research of Indiana University
  3. Direct For Biological Sciences
  4. Div Of Biological Infrastructure [1152030] Funding Source: National Science Foundation

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Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic, in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory.

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