Journal
SENSORS
Volume 11, Issue 7, Pages 6645-6655Publisher
MDPI
DOI: 10.3390/s110706645
Keywords
aptamer; biomolecular detection; ZnO-FET; sensor; riboflavin; selectivity; label-free; biofunctionalization
Funding
- Air Force Research Labs
- Bio-X Strategic Technology Thrust
- Materials and Manufacturing and Human Effectiveness Directorates
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Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag (ferrocene) to the 3' terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels.
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