Journal
SENSORS
Volume 11, Issue 9, Pages 8813-8825Publisher
MDPI AG
DOI: 10.3390/s110908813
Keywords
ion-selective electrode; ziprasidone; mixed solvents; pharmaceuticals; urine; serum
Funding
- Ministerio de Ciencia y Tecnologia, Spain [CTQ2008-04806/BQU]
- University of Murcia
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The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2: 3 (v/v) methanol/water medium from a ziprasidone concentration of 3 x 10(-6) M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.
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