Journal
SENSORS
Volume 10, Issue 4, Pages 3585-3596Publisher
MDPI
DOI: 10.3390/s100403585
Keywords
localized surface plasmon resonance (LSPR); metal nanoparticle; optical fiber sensor; self-assembly; immuno detection
Funding
- National Natural Science Foundation of China (NSFC) [20627002, 20773045, 20903043, 20973075]
- Jilin University [20805045]
- 111 project
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This article provides a novel method of constructing an optical fiber localized surface plasmon resonance (LSPR) biosensor. A gold nanoparticle (NP) assembled film as the sensing layer was built on the polyelectrolyte (PE) multilayer modified sidewall of an unclad optical fiber. By using a trilayer PE structure, we obtained a monodisperse gold NP assembled film. The preparation procedure for this LSPR sensor is simple and time saving. The optical fiber LSPR sensor has higher sensitivity and outstanding reproducibility. The higher anti-interference ability for response to an antibody makes it a promising method in application as a portable immuno-sensor.
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