Journal
SENSORS
Volume 10, Issue 4, Pages 3126-3144Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
DOI: 10.3390/s100403126
Keywords
peptide biosensors; environmentally-sensitive fluorophore
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Biosensors allow the direct detection of molecular analytes, by associating a biological receptor with a transducer able to convert the analyte-receptor recognition event into a measurable signal. We review recent work aimed at developing synthetic fluorescent molecular sensors for a variety of analytes, based on peptidic receptors labeled with environmentally sensitive fluorophores. Fluorescent indicators based on synthetic peptides are highly interesting alternatives to protein-based sensors, since they can be synthesized chemically, are stable, and can be easily modified in a site-specific manner for fluorophore coupling and for immobilization on solid supports.
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