Journal
SENSORS
Volume 10, Issue 5, Pages 4541-4557Publisher
MDPI
DOI: 10.3390/s100504541
Keywords
aptamer; biosensor; design strategy
Funding
- National Natural Science Foundation of China [20805020]
- Chinese Ministry of Education [109079]
- Jiangnan University [JUSRP10915]
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Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.
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