Journal
SENSORS
Volume 9, Issue 7, Pages 5600-5636Publisher
MDPI
DOI: 10.3390/s90705600
Keywords
DNA; single nucleotide mismatch; aptamers; bioconjugates; biosensors; impedance sensors; SPR; fluorescence sensors
Funding
- Promotion of Innovation by Science and Technology in Flanders (IWT)
- SBO [030219]
- IWT
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Bio-electronics is a scientific field coupling the achievements in biology with electronics to obtain higher sensitivity, specificity and speed. Biosensors have played a pivotal role, and many have become established in the clinical and scientific world. They need to be sensitive, specific, fast and cheap. Electrochemical biosensors are most frequently cited in literature, often in the context of DNA sensing and mutation analysis. However, many popular electrochemical transduction materials, such as silicon, are susceptible to hydrolysis, leading to loss of bioreceptor molecules from the surface. Hence, increased attention has been shifted towards diamond, which surpasses silicon on many levels.
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