Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep17267
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Funding
- Cancer Research UK - Bobby Moore Fund [C1298/A8362]
- Wellcome Trust
- DJ Fielding Medical Research Trust
- PhD studentship - Sir John Fisher Foundation
- NIH grants 5R01 [CA119215, 5R01 CA070917]
- American Brain Tumor Association
- National Brain Tumor Society
- Ligue Nationale contre le Cancer
- fondation ARC
- Institut National du Cancer (INCa) [PL046]
- French Ministry of Higher Education and Research
- program Investissements d'avenir [ANR-10-IAIHU-06]
- Genome Quebec, le Ministere de l'Enseignement superieur, de la Recherche, de la Science et de la Technologie (MESRST) Quebec
- McGill University
- Deutsche Forschungsgemeinschaft [Si552, Schr285]
- Deutsche Krebshilfe [70-2385-Wi2, 70-3163-Wi3, 10-6262]
- BONFOR
- German Federal Ministry of Education and Research (BMBF)
- Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg
- German National Genome Research Network (NGFN)
- Munich Center of Health Sciences (MC Health) as part of LMUinnovativ
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Genome-wide association studies (GWAS) have successfully identified a number of common single-nucleotide polymorphisms (SNPs) influencing glioma risk. While these SNPs only explain a small proportion of the genetic risk it is unclear how much is left to be detected by other, yet to be identified, common SNPs. Therefore, we applied Genome-Wide Complex Trait Analysis (GCTA) to three GWAS datasets totalling 3,373 cases and 4,571 controls and performed a meta-analysis to estimate the heritability of glioma. Our results identify heritability estimates of 25% (95% CI: 20-31%, P = 1.15 x 10(-17)) for all forms of glioma -26% (95% CI: 17-35%, P = 1.05 x 10(-8)) for glioblastoma multiforme (GBM) and 25% (95% CI: 17-32%, P = 1.26 x 10(-10)) for non-GBM tumors. This is a substantial increase from the genetic variance identified by the currently identified GWAS risk loci (similar to 6% of common heritability), indicating that most of the heritable risk attributable to common genetic variants remains to be identified.
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