Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 36, Issue 8, Pages 881-887Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0030-1267042
Keywords
Microparticle; platelet; megakaryocyte; cytoskeleton
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Funding
- NHLBI NIH HHS [R01 HL068130] Funding Source: Medline
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Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.
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