Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 35, Issue 5, Pages 488-496Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1234144
Keywords
Microparticles; endothelial cells; platelets; leukocytes; flow cytometry
Categories
Funding
- Heart Failure Association of the European Society of Cardiology
- Lancet International Fellowship
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Microparticles (MPs) are small (diameter <1 mu m) fragments that seem likely to represent some form of physiology and/or pathophysiology of the originating cell, be it endothelial, platelet, or leukocyte. Increased numbers of MPs are found in various disease states, including cardiovascular disease, and a considerable weight of literature suggests a value in dissecting the various aspects of cell biology. A role in coagulation has been proposed because there is evidence that some MPs expose tissue factor. This article reviews the definitions, mechanisms of production, and links with pathophysiology of MPs in arterial disease, and thus whether or not they can contribute to improved patient care.
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