Journal
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 35, Issue 5, Pages 531-544Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0034-1390023
Keywords
obstructive sleep apnea; inflammation; intermittent hypoxia; sympathetic nervous system activation
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Obstructive sleep apnea results in intermittent hypoxia via repetitive upper airway obstruction leading to partial or complete upper airway closure, apneas and hypopneas, respectively. Intermittent hypoxia leads to sympathetic nervous system activation and oxidative stress with a resultant systemic inflammatory cascade. The putative mechanism by which obstructive sleep apnea has been linked to numerous pathologic conditions including stoke, cardiovascular disease, hypertension, and metabolic derangements is through these systemic effects. Treatment of obstructive sleep apnea appears to reduce systemic markers of inflammation and ameliorates the adverse sequelae of this disease.
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