Journal
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 29, Issue 5, Pages 542-551Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0028-1085705
Keywords
tuberculosis; treatment; animal models; latent tuberculosis infection
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Funding
- NIAID NIH HHS [K08 AI058993] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI058993] Funding Source: NIH RePORTER
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Animal models have an important role in the preclinical evaluation of new antituberculosis drug candidates. Although it does not recapitulate the clinicopathological manifestations of tuberculosis in humans, the mouse remains the best characterized and most economical animal model for experimental chemotherapy. Provided care is taken to optimize the experimental conditions, the mouse has produced reliable data on the bactericidal and sterilizing activity of existing antituberculosis drugs and informed numerous clinical trials. Still, other animal models, especially the guinea pig, may have utility as confirmatory' or even alternative, models under certain circumstances. This chapter reviews some of the important considerations when selecting an animal model and presents a model for the sequential evaluation of a new compound with promising antituberculosis activity.
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