Journal
SEMINARS IN REPRODUCTIVE MEDICINE
Volume 27, Issue 3, Pages 207-217Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1216274
Keywords
Cytochrome P450 aromatase; CYP19; LH; sexual behavior; sexual partner preference; brain ischemia
Categories
Funding
- NIH [RR14270, NS049210]
- American Heart Association [0535284N]
- NATIONAL CENTER FOR RESEARCH RESOURCES [R01RR014270] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS049210] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Aromatization of testosterone to estradiol by neural tissue has classically been associated with the regulation of sexual differentiation, gonadotropin secretion, and copulatory, behavior. However, new data indicate that the capacity for aromatization is not restricted to the endocrine brain and demonstrate roles for locally formed estrogens in neurogenesis and in responses of brain tissue to injury. This article summaries our current understanding of the distribution and regulation of aromatase in the brain and describes the classic and novel roles it plays. A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available