Journal
SEMINARS IN REPRODUCTIVE MEDICINE
Volume 26, Issue 5, Pages 436-445Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0028-1087109
Keywords
Barker hypothesis; intrauterine stress; hypertension; cardiovascular disease; ART; low birth weight
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The developmental origin of health and disease hypothesis holds that events occurring during the early development of an individual and specifically during intrauterine life have profound consequences on future health. Low birth weight, a marker of intra-uterine stress, has been linked to predisposition to hypertension, cardiovascular diseases, diabetes, and stroke. The compelling animal evidence and significant human epidemiologic data to support this conclusion is reviewed. In addition, we propose that early embryo manipulation and Culture that occur during use of assisted reproductive technologies may represent a stressful event that could be associated with future health problems. The effects of embryo Culture on early development and gene expression and methylation status is reviewed and discussed.
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