Journal
SEMINARS IN NEPHROLOGY
Volume 32, Issue 3, Pages 287-294Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2012.04.008
Keywords
Retinol; retinoic acid; retinoic acid receptors; kidneys; immunology
Categories
Funding
- National Institute for Diabetes and Digestive and Kidney Disease Intramural Research Program
- Kidney Research UK Innovation Grant
- Kidney Research UK [IN1/2010] Funding Source: researchfish
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Transforming growth factor-beta (TGF-beta) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between these classes of molecules are, not surprisingly, highly complex and are dependent on the tissue, cellular, and molecular settings. Semin Nephrol 32:287-294 (C) 2012 Elsevier Inc. All rights reserved.
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