Journal
SEMINARS IN LIVER DISEASE
Volume 30, Issue 3, Pages 232-244Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0030-1255353
Keywords
LPS; TLR4; hepatic injury; fibrogenesis
Categories
Funding
- Fondation de la Recherche Medicale
- [U54CA126513]
- [R01DK076920]
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Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
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