Journal
SEMINARS IN LIVER DISEASE
Volume 29, Issue 2, Pages 141-154Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1214370
Keywords
Oxidative stress; alcoholic liver injury; reactive oxygen species; free radicals; antioxidants
Categories
Ask authors/readers for more resources
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as lipids, proteins, or DNA. This review describes pathways involved in ROS formation, why ROS are toxic to cells, and how the liver protects itself against ROS. Acute and chronic ethanol treatment increases the production of ROS, lowers cellular antioxidant levels, and enhances oxidative stress in man), tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol produces liver injury. Many pathways play a key role in how ethanol induces oxidative stress. This review Summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available