Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 36, Issue 2, Pages 261-274Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-013-0410-8
Keywords
Dendritic cells; Migration; Lymphatic vessels; Draining lymph node; CCL21
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Funding
- Swiss National Science Foundation [310030_138330]
- Swiss Government Excellence Scholarship
- Swiss National Science Foundation (SNF) [310030_138330] Funding Source: Swiss National Science Foundation (SNF)
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In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses.
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