Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 35, Issue 1, Pages 73-85Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-012-0328-6
Keywords
Hepatitis C; Hepatitis B; Hepatitis D; Autoimmunity; Immune complex disease; Molecular mimicry; Regulatory T cells; B lymphocyte activation
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Infections by the viruses responsible for hepatitis B, C and D are accompanied by a number of immunopathological manifestations. A link between infection and autoimmunity is particularly well documented for the hepatitis C virus. Immunopathological manifestations range from production of autoantibodies to overt autoimmune disease, including thyroiditis and autoimmune hepatitis, and to immune-complex-mediated disorders, including cryoglobulinaemia, glomerulonephritis and vasculitis. Several of these manifestations improve with successful antiviral treatment, directly incriminating the virus in their pathogenesis. Mechanisms considered responsible for hepatitis virus-related immunopathology, including molecular mimicry, impairment of regulatory T cells and activation of B lymphocytes, will be examined in this review.
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