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Th17 cytokines and vaccine-induced immunity

Journal

SEMINARS IN IMMUNOPATHOLOGY
Volume 32, Issue 1, Pages 79-90

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s00281-009-0191-2

Keywords

Th17; Infection; Vaccine-induced immunity

Funding

  1. Children's Hospital Of Pittsburgh
  2. Pennsylvania Department of Health Formula Funding
  3. National Institute of Health, USA [AI075106, A1083541]
  4. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI083541, R00AI075106] Funding Source: NIH RePORTER

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T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.

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