Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 33, Issue 1, Pages 67-87Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-010-0204-1
Keywords
Type 1 diabetes; NOD mice; Immunological tolerance; Genetics
Categories
Ask authors/readers for more resources
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type 1 diabetes (T1D). However, while sharing many similarities, it is becoming increasingly appreciated that there are also some differences in the immunopathogenic basis of T1D development between humans and NOD mice. This review will focus on aspects of T1D development in NOD mice that are similar and different from that in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available