Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 31, Issue 2, Pages 207-221Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-009-0157-4
Keywords
TNF superfamily members; Mucosal immune system; Intestinal inflammation
Categories
Funding
- National Institutes of Health [AI61516, AI06789001]
- NIDDK postdoctoral fellowship [DK082249]
- Crohn's & Colitis Foundation of America
- University of California, San Diego, Digestive Diseases Research Development Center [DK 080506]
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LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin family molecules, including B- and T-lymphocyte attenuator, which suppresses immune responses. Complexity in this pivotal system arises from several factors, including the non-monogamous pairing of ligands and receptors, and reverse signaling or the ability of some ligands to serve as receptors. As a result, recognition events in this fascinating network of interacting molecules can have pro- or anti-inflammatory consequences. Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation.
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