Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

Following specification of hematopoietic precursor cells into the T cell lineage, several developmental options remain available to the immature thymocytes. The paradigm is that the outcome of the T cell receptor rearrangements and the corresponding T cell receptor signaling events will be predominant to determine the first of these choices: the alpha beta versus gamma delta T cell pathways. Here, we review the thymus-derived environmental signals, the transcriptional mediators, and other molecular mechanisms that are also involved in this decision in both the mouse and human. We discuss the differences in cellular events between the alpha beta and gamma delta developmental pathways and try to correlate these with a corresponding complexity of the molecular mechanisms that support them.