Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 30, Issue 2, Pages 85-95Publisher
SPRINGER
DOI: 10.1007/s00281-008-0110-y
Keywords
complement system; complement regulatory proteins; eye; corneal inflammation; uveitis; age-related macular degeneration
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Funding
- NEI NIH HHS [EY014623, EY016205, R01 EY014623, R01 EY016205] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY014623, R01EY016205] Funding Source: NIH RePORTER
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Functionally active complement system and complement regulatory proteins are present in the normal human and rodent eye. Complement activation and its regulation by ocular complement regulatory proteins contribute to the pathology of various ocular diseases including keratitis, uveitis and age-related macular degeneration. Furthermore, a strong relationship between age-related macular degeneration and polymorphism in the genes of certain complement components/complement regulatory proteins is now well established. Recombinant forms of the naturally occurring complement regulatory proteins have been exploited in the animal models for treatment of these ocular diseases. It is hoped that in the future recombinant complement regulatory proteins will be used as novel therapeutic agents in the clinic for the treatment of keratitis, uveitis, and age-related macular degeneration.
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