Journal
SEMINARS IN IMMUNOLOGY
Volume 26, Issue 1, Pages 48-53Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.01.007
Keywords
Metastasis; Microenvironment; Cancer
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Funding
- Astra Zeneca
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IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed. (C) 2014 Published by Elsevier Ltd.
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