Journal
SEMINARS IN IMMUNOLOGY
Volume 26, Issue 2, Pages 107-113Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.01.006
Keywords
NK cells; ILC2; ILC3; ILC development; NCR
Categories
Funding
- Associazione Italiana Ricerca sul Cancro (AIRC) [IG 2010, 10225]
- Special Program Molecular Clinical Oncology 5 x 1000 [9962]
- Ministero della Salute [RF2010, RF-2010-2316606]
- MIUR-PRIN [2009T4TC33_004]
- Ricerca Finalizzata [RF-IG-2008-1200689]
- Progetto Ricerca Ateneo
- International Leibniz Research Cluster (ILRC)
- Senatsausschuss Wettbewerb (SAW)
- Fondazione Italiana per la Ricerca sul Cancro (FIRC)
Ask authors/readers for more resources
Innate lymphoid cells (ILC) have recently gained much attention in immunology. They represent a novel developmentally related family. Three distinct subsets have been identified on the basis of phenotypic and functional criteria and termed ILC1, ILC2, and ILC3. The available data suggest that ILC play an important role in innate defenses against different pathogens, in lymphoid organogenesis, and in tissue remodeling. All these aspects are relevant in hematopoietic stem cell transplantation (HSCT), particularly in the haplo-HSCT setting, in which donor NM cells are known to play a major therapeutic role, while the involvement of other ILC is still undefined. In this context, it has been postulated that all ILC share a common precursor expressing the ID2 transcription factor. While the differentiation of human NM cells (belonging to ILC1) is now well characterized both in vitro and in vivo, limited information is available on the development of human ILC2 and ILC3 and of their relationships with NM cells. In this review, we will summarize the present knowledge on the developmental relationship among different ILC, with particular focus on early stages of NM cell differentiation, and their features shared with ILC2 and ILC3. (c) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available