Journal
SEMINARS IN IMMUNOLOGY
Volume 26, Issue 3, Pages 237-245Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.02.009
Keywords
TNF; MAP kinase; ERK; JNK; p38 MAP kinase
Categories
Funding
- Ministry of Economy and Competitiveness
- Pro-CNIC Foundation
- Ramon y Cajal Program
- [ERC 260464]
- [EFSD 2030]
- [MICINN SAF2010-19347]
- [Comunidad de Madrid S2010/BMD-2326]
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The binding of tumour necrosis factor alpha (TNF alpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNF alpha) that contribute to the biological activity of TNF alpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFa receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNF alpha. (C) 2014 Elsevier Ltd. All rights reserved.
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