Journal
SEMINARS IN IMMUNOLOGY
Volume 25, Issue 1, Pages 2-11Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2013.04.009
Keywords
Complement; Anaphylatoxins; Allergic asthma; Dendritic cells; T cells; Myeloid suppressor cells
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB/TR22, SFB654, IRTG 1911, KO 1245-3/1]
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Allergic asthma is a chronic disease of the airways in which maladaptive Th2 and Th17 immune responses drive airway hyperresponsiveness (AHR), eosinophilic and neutrophilic airway inflammation and mucus overproduction. Airway epithelial and pulmonary vascular endothelial cells in concert with different resident and monocyte-derived dendritic cells (DC) play critical roles in allergen sensing and consecutive activation of TH cells and their differentiation toward TH2 and TH17 effector or regulatory T cells (Treg). Further, myeloid-derived regulatory cells (MDRC) act on TH cells and either suppress or enhance their activation. The complement-derived anaphylatoxins (AT) C3a and C5a are generated during initial antigen encounter and regulate the development of maladaptive immunity at allergen sensitization. Here, we will review the complex role of ATs in activation and modulation of different DC populations, MDRCs and CD4+ TH cells. We will also discuss the potential impact of ATs on the regulation of the pulmonary stromal compartment as an important means to regulate DC functions. (C) 2013 Elsevier Ltd. All rights reserved.
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