Journal
SEMINARS IN IMMUNOLOGY
Volume 25, Issue 1, Pages 20-28Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2013.04.013
Keywords
C3a; C5a; Organ transplantation; Reperfusion injury; Graft rejection; Transplant tolerance
Categories
Funding
- Medical Research Council of the UK [G0601202, G1001141, G0600892]
- National Natural Science Foundation of China [NSFC 81000922, 81170644]
- MRC [G0600892, G0601202] Funding Source: UKRI
- Medical Research Council [G0600892, G1001141, G0601202, MR/J006742/1] Funding Source: researchfish
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C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses. Organ transplantation triggers an initial inflammatory response and subsequent to the specific immune response (also called the alloimmune response), both of which contribute to graft rejection. Emerging evidence suggests that anaphylatoxins, particularly C5a, are significantly involved in both inflammatory and alloimmune responses following organ transplantation, thus influencing graft outcome. This review will provide the information on our current understanding of the roles for anaphylatoxins in ischemia-reperfusion injury, graft rejection, and transplant tolerance, and the therapeutic potential of targeting anaphylatoxin receptors in organ transplantation. (C) 2013 Elsevier Ltd. All rights reserved.
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