Journal
SEMINARS IN IMMUNOLOGY
Volume 25, Issue 5, Pages 358-363Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2013.09.004
Keywords
Immunoglobulin A; Commensal bacteria; Intestinal mucus; Mucosal immunity; Intestinal homeostasis; Host-microbial superorganism
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The gastrointestinal tract is heavily colonized with commensal microbes with the concentration of bacteria increasing longitudinally down the length of the intestine. Bacteria are also spatially distributed transversely from the epithelial surface to the intestinal lumen with the inner mucus layer normally void of bacteria. Maintenance of this equilibrium is extremely important for human health and, as the dominant immunoglobulin at mucosal sites, IgA influences mutualism between the host and its normal microbiota. In this review we focus on the links between immune and microbial geography of the mammalian intestinal tract. (C) 2013 Elsevier Ltd. All rights reserved.
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